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Pressure Controlled Ventilation to Induce Acute Lung Injury in Mice
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May 05, 2011
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A murine model for ventilator induced lung injury is an important tool to study an acute lung injury in vivo. Here, we report an easy applicable in situ model for acute lung injury using high-pressure mechanical ventilation to induce acute failure of the lung.
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Pressure Controlled VentilationAcute Lung InjuryALIMiceMurine ModelsMechanical VentilationGenetic TargetsPharmacological TargetsPulmonary EdemaPulmonary Gas ExchangeVentilator-induced Lung InjuryC57BL/6 MiceTracheotomyInspiratory Peak PressureOutcome ParametersWet-to-dry RatioBronchoalveolar Fluid Albumin ContentMyeloperoxidase ContentPulmonary InflammationTreatment GroupsGenotypesGene-targeted Deletion
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Koeppen, M., Eckle, T., Eltzschig, H. K. Pressure Controlled Ventilation to Induce Acute Lung Injury in Mice. J. Vis. Exp. (51), e2525, doi:10.3791/2525 (2011).
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