Mechanically-gated ion channels are transmembrane proteins that open in response to various stimuli like pressure, touch, sound, and temperature. Through these open channels, ions move down their electrochemical gradient depolarizing the membrane. This leads to the propagation of an action potential to the central nervous system to induce appropriate responses. The most extensively studied PIEZO channels open in response to mechanical stress like touch and pressure. Interestingly, these channels respond not only to external stimuli but are also internal sensors for blood pressure regulation and breathing. Another type, TRP ion channels, have a broad role in sensory perception. On touching a hot surface, TRPV1, a temperature-gated ion channel at the nerve ending, opens. Sodium and calcium ions pass through this open channel, changing the nerve fibers' membrane potential. This generates an action potential that travels to the brain, triggering a painful and burning sensation.