Vitamins— A, C, D, K, and B12 are crucial for maintaining bone strength and health in the human body. Vitamin A plays a significant role in stimulating osteoblasts activity and differentiation. While in children, it promotes bone growth; in adults, it influences the maintenance of bone health. Vitamin C acts as a cofactor for the enzymes responsible for the hydroxylation of specific residues on the collagen that increase their stability. Vitamin D helps in the uptake of dietary calcium and phosphate from the gastrointestinal tract. These minerals are essential for the formation of bone matrix. Osteocalcin— a protein secreted by osteoblasts requires Vitamin K for its carboxylation and enzymatic activation. This carboxylated osteocalcin has a high calcium-binding affinity and aids in bone mineralization. As a result, vitamin K deficiency can lead to a rise in the level of uncarboxylated osteocalcin, reducing bone mineral density and increasing the risk of fractures. Similarly, vitamin B12 deficiency can also lead to low bone mineral density and even contribute to osteoporosis, especially in women.