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Flow Analysis of PDL1-Vaxx Antibody Blockade Using Magnetic Fluorescent Beads

Flow Analysis of PDL1-Vaxx Antibody Blockade Using Magnetic Fluorescent Beads

July 07, 2023

Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction

02:48 min
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PD-L1 Magnetic Bead-Based PD-1/PD-L1 Blocking Assay

07:24 min
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1Department of Obstetrics & Gynecology,The Ohio State University Wexner Medical Center, 2The James Comprehensive Cancer Center

Özet

Checkpoint inhibitors are important targets in developing therapies for the battle against cancer. This report introduces a novel PDL1 peptide-based cancer vaccine, PDL1-Vaxx, which induces neutralizing polyclonal antibody production that blocks PD-1/PDL1 complex formation. This work also details the development and testing of a fluorescent bead-based assay for analyzing this activity.

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