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Screening of ?2 Integrin Activation Inhibitors in Human Neutrophils

Screening of ?2 Integrin Activation Inhibitors in Human Neutrophils

February 02, 2024

Author Spotlight: Development of a Method for Identifying Small Molecular Antagonists of β2 Integrin Activation

00:45 min
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High-Throughput Screening of Compounds Using Neutrophils Isolated from Human Blood in a 384-Well Plate Format

02:35 min
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Neutrophils Screening Assay Using Flow Cytometry

01:03 min
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1Department of Immunology, School of Medicine,UConn Health, 2Center for Molecular Discovery,University of New Mexico Health Sciences Center, 3Comprehensive Cancer Center,University of New Mexico Health Sciences Center, 4Patoloji Bölümü,University of New Mexico Health Sciences Center, 5Autophagy, Inflammation, & Metabolism (AIM) Center,New Mexico Üniversitesi

Özet

This protocol describes a flow cytometry-based, high-throughput screening method to identify small-molecule drugs that inhibit β2 integrin activation on human neutrophils.

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