The NMR spectroscopy of spin-half nuclei such as nitrogen-15, fluorine-19, and phosphorus-31 has wide-ranging applications in chemistry and biology. Among these nuclei, nitrogen-15 has a low natural abundance and a negative magnetogyric ratio. The chemical shifts of these nuclei require specific standard references and have different ranges. For nitrogen-15, chemical shifts are lowest in saturated systems and become increasingly positive with electronegative substitution. However, the lone electron pair can undergo coordination and protonation with the solvent, varying the chemical shifts. Fluorine-19 chemical shifts are also solvent-dependent, though primarily influenced by paramagnetic shielding effects. Most organofluorine compounds appear in a smaller range of 350 ppm. Interestingly, phosphorus-31 chemical shifts are more affected by the coordination number of phosphorus than by the electronegative substituents.