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2.3:

Efeitos de Substâncias Químicas: Visão Geral

JoVE Core
Pharmacology
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JoVE Core Pharmacology
Effects of Chemicals: Overview

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Drugs are chemical substances obtained naturally, synthetically, or through genetic engineering. When administered in a living body, drugs produce numerous biological effects that may be classified as desirable or therapeutic or undesirable. The main objective of a desirable effect is to treat the disease. All other effects experienced alongside the desirable effect are considered undesirable, which can be further classified into side effects and toxic effects. Side effects are generally nondeleterious. They are the drugs' unwanted and unavoidable pharmacodynamic effects. Drugs like atropine used to reduce mucous secretions can cause side effects like dry mouth due to the same action that produces the therapeutic effect. Toxic effects are deleterious and categorized as pharmacological, pathological, or genotoxic. Pharmacological effects of drugs arise from excessive or prolonged drug usage and generally disappear as the drug is biotransformed or excreted, reducing its concentration in the body. Pathological and genotoxic effects are, in many instances, repairable, but if the effects are very severe, they may lead to cancer or death.

2.3:

Efeitos de Substâncias Químicas: Visão Geral

Drugs, encompassing various chemical compounds from natural sources, lab synthesis, or genetic engineering, elicit different biological responses in living organisms. Some of these responses are desirable or therapeutic, while others are undesirable. The primary goal of administering a drug is to achieve a therapeutic effect, that is, to address a specific disease or health condition. Any concurrent effects outside of this therapeutic outcome are considered undesirable. These undesirable effects fall into two categories: side effects and toxic effects. Side effects, although unwanted, are an inevitable part of a drug's pharmacodynamic action. They are generally not harmful but can cause discomfort. For example, atropine, used to reduce mucus production, can unintentionally cause dry mouth due to its primary mechanism of action. On the other hand, toxic effects are harmful and can be grouped into pharmacological, pathological, or genotoxic effects. Pharmacological toxicity often results from overuse or prolonged consumption of a drug. It usually subsides once the drug is metabolized or excreted, reducing its concentration in the body. Pathological and genotoxic effects can be reversed, but some severe cases may lead to serious health problems like cancer or death.