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卯木反应的优化使用平行合成和自动化液体处理
JoVE Journal
Biologia
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JoVE Journal Biologia
Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling
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卯木反应的优化使用平行合成和自动化液体处理

16,087 Views

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08:24 min

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November 11, 2008

DOI:

10.3791/942-v

DOI:
10.3791/942-v

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08:24 min
November 11, 2008

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5 Views
, , , ,
1Department of Chemistry,Drexel University, 2Mettler-Toledo, 3Chemspider

Summary

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卯木的反应已被证明是一种方便的方式快速创建不同化合物库。它涉及胺的反应，醛，羧酸和腈在甲醇中，在室温下通常。在这段视频中，我们利用配备过滤管和一个梅特勒 - 托利多MiniMapper自动化液体处理程序是用来提供的试剂和溶剂48槽梅特勒 - 托利多MiniBlock。感兴趣的参数的浓度，溶剂组成和试剂的一些多余的。

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Bradley, J., Baig Mirza, K., Osborne, T., Wiliams, A., Owens, K. Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling. J. Vis. Exp. (21), e942, doi:10.3791/942 (2008).

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