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卯木反应的优化使用平行合成和自动化液体处理
JoVE Journal
Biologia
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JoVE Journal Biologia
Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling
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卯木反应的优化使用平行合成和自动化液体处理

16,086 Views

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08:24 min

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November 11, 2008

DOI:

10.3791/942-v

DOI:
10.3791/942-v

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08:24 min
November 11, 2008

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5 Views
, , , ,
1Department of Chemistry,Drexel University, 2Mettler-Toledo, 3Chemspider

Summary

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卯木的反应已被证明是一种方便的方式快速创建不同化合物库。它涉及胺的反应，醛，羧酸和腈在甲醇中，在室温下通常。在这段视频中，我们利用配备过滤管和一个梅特勒 - 托利多MiniMapper自动化液体处理程序是用来提供的试剂和溶剂48槽梅特勒 - 托利多MiniBlock。感兴趣的参数的浓度，溶剂组成和试剂的一些多余的。

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Cite this Article

Bradley, J., Baig Mirza, K., Osborne, T., Wiliams, A., Owens, K. Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling. J. Vis. Exp. (21), e942, doi:10.3791/942 (2008).

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