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Mechanical Control of Relaxation Using Intact Cardiac Trabeculae
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Medicina
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JoVE Journal Medicina
Mechanical Control of Relaxation Using Intact Cardiac Trabeculae

Mechanical Control of Relaxation Using Intact Cardiac Trabeculae

DOI:
10.3791/64879-v

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07:51 min

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February 17, 2023

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, , ,
1Department of Physiology,Wayne State University, 2School of Medicine, Michigan State University-Macomb and Department of Physiology,Wayne State University

Capítulos

  • 00:04Introduction
  • 00:55Isolation and Equilibration of Trabecula
  • 04:27Data Acquisition
  • 05:42Data Analysis
  • 06:28Results: Strain Rate Determination
  • 07:13Conclusion

Summary

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Rapid myocardial and cardiac relaxation is essential for normal physiology. Mechanical relaxation mechanisms are now known to be dependent on strain rate. This protocol provides an overview of the acquisition and analysis of experiments to further study the mechanical control of relaxation.

Tags

Cardiac RelaxationMechanical ControlCardiac TrabeculaeDiastolic DiseasesMuscle RelaxationRodent HeartTrabecular IsolationRight Ventricular Outflow TractVannas ScissorsBlunt-end Melted Glass PipettePapillary MusclesPerfusion SolutionModified Tyrode’s Solution

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