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A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
JoVE Journal
Biologia
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JoVE Journal Biologia
A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
DOI:

09:18 min

July 28, 2023

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Capítulos

  • 00:04Introduction
  • 01:05HuMiX Start
  • 04:12Cell Preparation and Inoculation
  • 06:23HuMiX Opening and Sampling on Day 14
  • 07:51Results: Limosilactobacillus reuteri CFU Count and Evaluating the Enteric Neuron Phenotype Alterations Within the Device
  • 08:47Conclusion

Summary

Tadução automática

neuroHuMiX is an advanced gut-on-a-chip model to study the interactions of bacterial, epithelial, and neuronal cells under proximal and representative co-culture conditions. This model allows unravelling of the molecular mechanisms underlying the communication between the gut microbiome and the nervous system.

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