This protocol provides methods for generating 3D engineered cardiac and skeletal muscle tissues and describes their use in preclinical drug screening modalities. The described methods utilize a magnetic sensing system to facilitate the simultaneous assessment of 24 tissues in parallel.
Berry, B. J., Luttrell, S. M., Moerk, C. T., Macadangdang, J., Perez, J., Gray, K., Ghazizadeh, H., Kharoufeh, S., Nelsen, B., Geisse, N. A. Preclinical Drug Testing in Scalable 3D Engineered Muscle Tissues. J. Vis. Exp. (194), e64399, doi:10.3791/64399 (2023).