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成人皮层的器官型培养作为人类干细胞移植和验证的离体模型

JoVE Journal
Neurociência

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JoVE Journal Neurociência

Organotypic Cultures of Adult Human Cortex as an Ex vivo Model for Human Stem Cell Transplantation and Validation

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成人皮层的器官型培养作为人类干细胞移植和验证的离体模型

2,131 Views

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07:16 min

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December 09, 2022

DOI:

10.3791/64234-v

DOI:

10.3791/64234-v

•

07:16 min

December 09, 2022

•

30 Views

Sara Palma-Tortosa¹, Raquel Martínez-Curiel¹, Constanza Aretio-Medina¹, Natalia Avaliani², Zaal Kokaia¹

¹Laboratory of Stem Cells and Restorative Neurology, Lund Stem Cell Center,Lund University, ²Lund Stem Cell Center,Lund University

Summary

该协议描述了成人皮层的长期器官型培养与诱导多能干细胞衍生皮质祖细胞的离体皮质内移植相结合，这提供了一种新方法来进一步测试基于干细胞的治疗人类神经退行性疾病。

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