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Microfluidic Device for the Separation of Non-Metastatic (MCF-7) and Non-Tumor (MCF-10A) Breast Cancer Cells Using AC Dielectrophoresis
JoVE Journal
Engenharia
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JoVE Journal Engenharia
Microfluidic Device for the Separation of Non-Metastatic (MCF-7) and Non-Tumor (MCF-10A) Breast Cancer Cells Using AC Dielectrophoresis
DOI:

08:33 min

August 11, 2022

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Capítulos

  • 00:05Introduction
  • 00:43Chip Design and Parameter Selection
  • 04:01Mathematical Model and Computational Analysis
  • 05:59Results: Investigating the Optimal Operational Parameters for Effective DEP-Based Sorting
  • 07:59Conclusion

Summary

Tadução automática

Breast cancer cells exhibit different dielectric properties compared to non-tumor breast epithelial cells. It has been hypothesized that, based on this difference in dielectric properties, the two populations can be separated for immunotherapy purposes. To support this, we model a microfluidic device to sort MCF-7 and MCF-10A cells.

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