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Mechanical Conflict-Avoidance Assay to Measure Pain Behavior in Mice
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JoVE Journal Neurociência
Mechanical Conflict-Avoidance Assay to Measure Pain Behavior in Mice

Mechanical Conflict-Avoidance Assay to Measure Pain Behavior in Mice

DOI:
10.3791/63454-v

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06:57 min

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February 18, 2022

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, , , ,
1Laboratories of Neuroimmunology, Department of Symptom Research, and the MD Anderson Pain Research Consortium,University of Texas MD Anderson Cancer Center, 2Department of Anesthesiology, Perioperative and Pain Medicine,Stanford University School of Medicine

Capítulos

  • 00:04Introduction
  • 00:39Mechanical Conflict-Avoidance (MCA) Construction
  • 02:27Mouse MCA Habituation and Testing
  • 04:49Results: MCA Assay Analysis of Inflammatory, Neuropathic, and Fracture/Casting Induced Pain Augmentation Avoidance
  • 06:20Conclusion

Summary

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The mechanical conflict-avoidance assay is used as a non-reflexive readout of pain sensitivity in mice which can be used to better understand affective-motivational responses in a variety of mouse pain models.

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Keywords: Mechanical Conflict-avoidance AssayPain BehaviorMicePreclinical ResearchTranslational ResearchAcrylic ChamberLED IlluminationProbe ArrayNylon 12 PlasticAcclimationVideo Recording

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