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Neuroscience

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JoVE Journal Neuroscience
A Mouse Model of Direct Anastomosis via the Prespinal Route for Crossing Nerve Transfer Surgery
 

A Mouse Model of Direct Anastomosis via the Prespinal Route for Crossing Nerve Transfer Surgery

Article DOI: 10.3791/63051-v • 05:56 min • October 19th, 2021
October 19th, 2021 •
*1,2, *1, *1, 1, 1, 1, 1, 1,2,3,4,5, 1,2,3,4,5
1Department of Hand Surgery, Huashan Hospital, Fudan University, 2Department of Hand and Upper Extremity Surgery, Jing‘an District Central Hospital, Fudan University, 3The National Clinical Research Center for Aging and Medicine, Fudan University, 4Institutes of Brain Science, Fudan University, 5State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center of Brain Science, Fudan University
* These authors contributed equally

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We simulated clinical surgery to establish a protocol of direct anastomosis of bilateral brachial plexus nerves via the prespinal route in mice, contributing to the study of the neural mechanisms underlying rehabilitation upon crossing nerve transfer after central and peripheral nervous system injuries.

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Prespinal Route Nerve Transfer Surgery Brachial Plexus Avulsion Injuries Upper Extremity Repair Brain Injury Treatment Functional Recovery Neuroplasticity Peripheral Sensorimotor Intervention Neural Mechanism Clinical Animal Model Bilateral Brachial Plexus Nerves Neuroanatomical Experiments Electrophysiological Experiments Behavioral Experiments Reinnervation Impaired Forelimb Motor Recovery
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