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Preparation and Implantation of Electrodes for Electrically Kindling VGAT-Cre Mice to Generate a Model for Temporal Lobe Epilepsy
JoVE Journal
Neurociência
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JoVE Journal Neurociência
Preparation and Implantation of Electrodes for Electrically Kindling VGAT-Cre Mice to Generate a Model for Temporal Lobe Epilepsy
DOI:

09:29 min

August 17, 2021

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Capítulos

  • 00:04Introduction
  • 00:56Headsets Preparation with Two Bipolar Electrodes
  • 03:24Stereotaxic Electrode Implantation
  • 07:38Results: Study of the Spontaneous Recurring Seizures (SRS) After Electrical Kindling of VGAT-Cre Mice
  • 08:30Conclusion

Summary

Tadução automática

This report describes the methods to generate a model of temporal lobe epilepsy based on the electrical kindling of transgenic VGAT-Cre mice. Kindled VGAT-Cre mice may be useful in determining what causes epilepsy and for screening novel therapies.

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