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小鼠硬脑膜刺激和眶周冯弗雷测试作为头痛的临床前模型

JoVE Journal
Neurociência

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JoVE Journal Neurociência

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

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小鼠硬脑膜刺激和眶周冯弗雷测试作为头痛的临床前模型

DOI:

10.3791/62867-v

•

05:40 min

•

July 29, 2021

•

Bianca N. Mason, Amanda Avona, Jacob Lackovic, Gregory Dussor

¹School of Brain and Behavioral Sciences and Center for Advanced Pain Studies,University of Texas at Dallas

Capítulos

00:05Introduction
00:36Dural Infuser
02:12Dural Injections
03:11Periorbital von Frey
04:14Results: Dural Prolactin Stimulation in Mice as a Preclinical Headache Model
05:07Conclusion

Summary

Tadução automática

偏头痛最显着的症状是严重的头部疼痛，据推测这是由支配脑膜的感觉神经元介导的。在这里，我们提出了一种以微创方式局部将物质应用于硬脑膜的方法，同时使用面部超敏反应作为输出。

Tags

Keywords: Dural Stimulation Periorbital Von Frey Testing Preclinical Headache Model Meningeal Pain Genetically Modified Mice Dura Mater Injection Suture Location Infuser Design Microsyringe Anesthesia Animal Preparation

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