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Triagem de fragmentos baseada em RMN em uma amostra mínima, mas no modo de automação máxima

JoVE Journal
Bioquímica

This content is Free Access.

JoVE Journal Bioquímica

NMR-Based Fragment Screening in a Minimum Sample but Maximum Automation Mode

Triagem de fragmentos baseada em RMN em uma amostra mínima, mas no modo de automação máxima

2,512 Views

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09:19 min

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June 04, 2021

DOI:

10.3791/62262-v

DOI:

10.3791/62262-v

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09:19 min

June 04, 2021

•

5 Views

Hannes Berg*¹, M. A. Wirtz Martin*¹, A. Niesteruk², C. Richter, S. Sreeramulu, H. Schwalbe²

¹Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ),Johann Wolfgang Goethe-University Frankfurt, ²German Cancer Consortium (DKTK) and DKFZ

Tags

NMR Fragment Screening Protein Structure Biomolecular Targets Small Molecule Fragments Ligand Binding Sample Preparation Automated Screening 1D NMR 2D NMR T1r T2 Saturation Transfer Difference WaterLOGSY Data Processing Fragment-based Screening Tool

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