We present a behavioral chamber designed to assess cognitive performance. We provide data showing that once acquired, zebrafish remember the task 8 weeks later. We also show that hyperglycemic zebrafish have altered cognitive performance, indicating that this paradigm is applicable to studies assessing cognition and memory.
Rowe, C. J., Crowley-Perry, M., McCarthy, E., Davidson, T. L., Connaughton, V. P. The Three-Chamber Choice Behavioral Task using Zebrafish as a Model System. J. Vis. Exp. (170), e61934, doi:10.3791/61934 (2021).