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10:20 min
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March 02, 2020
DOI:
1The Department of Physiology and Cell Biology, Faculty of Health Sciences,Ben-Gurion University of the Negev, 2The Regenerative Medicine and Stem Cell (RMSC) Research Center,Ben-Gurion University of the Negev, 3The Zlotowski Center for Neuroscience,Ben-Gurion University of the Negev, 4The Board of Governors Regenerative Medicine Institute,Cedars-Sinai Medical Center, 5Division of Micro and Nanosystems,KTH Royal Institute of Technology, 6AIMES, Department of Neuroscience,Karolinska Institutet
Summary
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血脑屏障（BBB）是一种多细胞神经血管单元，严密调节大脑平衡。通过结合人类 iPSC 和芯片上器官技术，我们生成了个性化的 BBB 芯片，适用于疾病建模和 CNS 药物渗透性预测。介绍了BBB芯片的生成和运行的详细方案。
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Cite this Article
Jagadeesan, S., Workman, M. J., Herland, A., Svendsen, C. N., Vatine, G. D. Generation of a Human iPSC-Based Blood-Brain Barrier Chip. J. Vis. Exp. (157), e60925, doi:10.3791/60925 (2020).
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