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JoVE Journal Developmental Biology
Generation of a Human iPSC-Based Blood-Brain Barrier Chip
 

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Article DOI: 10.3791/60925-v • 10:20 min • March 2nd, 2020
March 2nd, 2020 •
1,2,3, 4, 5,6, 4, 1,2,3
1The Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 2The Regenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, 3The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, 4The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 5Division of Micro and Nanosystems, KTH Royal Institute of Technology, 6AIMES, Department of Neuroscience, Karolinska Institutet

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Resumen
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The blood-brain barrier (BBB) is a multicellular neurovascular unit tightly regulating brain homeostasis. By combining human iPSCs and organ-on-chip technologies, we have generated a personalized BBB chip, suitable for disease modeling and CNS drug penetrability predictions. A detailed protocol is described for the generation and operation of the BBB chip.

Tags

Human IPSC-based Blood-brain Barrier Organ-on-chip Microfluidic Drug Permeability Neurological Disorders Personalized BBB Chips Neurological Disease Pharma Companies Candidate Neurological Drugs Penetrability Organ-on-chip Technologies Specialized Engineering Skills Biosafety Cabinet Neural Differentiation Medium
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