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Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury
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Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury

DOI:
10.3791/60360-v

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07:07 min

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February 10, 2020

•

,
1Fralin Biomedical Research Institute at Virginia Tech Carilion, 2School of Neuroscience,Virginia Tech, 3Department of Biological Sciences,Virginia Tech

Capítulos

  • 00:04Título
  • 00:56Weight Drop Traumatic Brain Injury (TBI)
  • 02:01Electroencephalography (EEG) Electrode Implantation Surgical Field Preparation
  • 03:11EEG Electrode Implantation
  • 05:13Results: Representative Spontaneous Seizure Depictions and Timelines
  • 06:17Conclusion

Summary

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This systematic protocol describes a new animal model of post-traumatic epilepsy after repetitive mild traumatic brain injury. The first part details steps for traumatic brain injury induction using a modified weight drop model. The second part provides instructions on the surgical approach for single- and multi-channel electroencephalographic data acquisition systems.

Tags

Post-traumatic EpilepsyMouse ModelTraumatic Brain InjuryDiffuse InjuryBiomarkersTreatmentsMild Traumatic Brain InjuryConcussionEEG Electrode ImplantationStereotactic ApparatusPeriosteumCraniumHigh-speed Drill

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