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Intrathecal Delivery of Antisense Oligonucleotides in the Rat Central Nervous System
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Intrathecal Delivery of Antisense Oligonucleotides in the Rat Central Nervous System
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October 29, 2019
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Here, we describe a method for delivering drugs to the rat central nervous system by implanting a catheter into the lumbar intrathecal space of the spine. We focus on the delivery of antisense oligonucleotides, though this method is suitable for delivery of other therapeutic modalities as well.
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Chen, Y., Mazur, C., Luo, Y., Sun, L., Zhang, M., McCampbell, A., Tomassy, G. S. Intrathecal Delivery of Antisense Oligonucleotides in the Rat Central Nervous System. J. Vis. Exp. (152), e60274, doi:10.3791/60274 (2019).
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