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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
Capítulos
- 00:05Título
- 01:021-Phenyl-2-Propyne-1-One Synthesis
- 02:294-Nitronitrosobenzene Preparation
- 03:373-Benzoyl-1-Hydroxy-5-Nitroindole Synthesis
- 04:48Results: Representative 3-Aroyl-N-Hydroxy-5-Nitroindole Synthesis
- 06:32Conclusion
3-Aroyl-N-hydroxy-5-nitroindoles were synthesized by cycloaddition of 4-nitronitrosobenzene with a conjugated terminal alkynone in a one-step thermal procedure. Preparation of the nitrosoarene and of the alkynones were adequately reported and respectively through oxidation procedures on the corresponding aniline and on the alkynol.
