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通过化学测量方法，从活体共聚焦拉曼光谱中解决水、蛋白质和脂质

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Química

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JoVE Journal Química

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

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通过化学测量方法，从活体共聚焦拉曼光谱中解决水、蛋白质和脂质

DOI:

10.3791/60186-v

•

09:32 min

•

September 26, 2019

•

Lesheng Zhang*¹, Tom Cambron*², Yueqing Niu, Zigang Xu, Ning Su, Hongyan Zheng, Karl Wei, Paula Ray

¹Procter and Gamble,Beijing Innovative center, ²Procter and Gamble,Mason Business Center, ³Department of Dermatology,Beijing Children’s Hospital, ⁴Chinese Academy of Inspection and Quarantine

Capítulos

00:04Título
01:22Collection of In Vivo Confocal Raman Spectra from Human Subjects with Atopic Dermatitis
02:10Removal of the Out-of-skin Spectra
04:38Removing the Outlier Spectra with the Room Light Effect
06:16Selection of the Number of Components in MCR Decomposition Analysis
07:35Results: Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum
08:56Conclusion

Summary

Tadução automática

在这里，我们提出了一个方案，从临床研究中从人类受试者收集共聚焦拉曼光谱，结合化学方法去除光谱异常值和随后提取关键特征。

Tags

Keywords: In Vivo Confocal Raman Spectroscopy Stratum Corneum Water Proteins Lipids Chemometrics Data Preprocessing Baseline Correction Outlier Detection Depth Profiling

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