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The Chick Chorioallantoic Membrane In Vivo Model to Assess Perineural Invasion in Head and Neck Cancer
 

The Chick Chorioallantoic Membrane In Vivo Model to Assess Perineural Invasion in Head and Neck Cancer

Article DOI: 10.3791/59296-v • 09:16 min • June 21st, 2019
June 21st, 2019 •
1, 1, 1, 1, 1,2
1Periodontics and Oral Medicine, University of Michigan School of Dentistry, 2Pathology, University of Michigan Medical School

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Resumo
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Perineural invasion is an aggressive phenotype for head and neck squamous cell carcinomas and other tumors. The chick chorioallantoic membrane model has been used for studying angiogenesis, cancer invasion, and metastasis. Here we demonstrate how this model can be utilized to assess perineural invasion in vivo.

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Chick Chorioallantoic Membrane In Vivo Model Perineural Invasion Head And Neck Cancer Tumor Cells Nerves Molecular Pathways Experimental Time Cancer Phenotypes Drilling Eggs Dorsal Root Ganglia Incubating Eggs Pathogen-free Fertilized Eggs Egg Humidifying Incubator Rat Spine Removal Cervical Region Thoracic Region Lumbar Region Culture Dish PBS Spine Sections Spinal Cord Detachment
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