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登革热病毒诱发急性病毒性脑炎样疾病的鼠害模型

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Imunologia e Infecção

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JoVE Journal Imunologia e Infecção

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

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登革热病毒诱发急性病毒性脑炎样疾病的鼠害模型

6,374 Views

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04:23 min

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April 28, 2019

DOI:

10.3791/59132-v

DOI:

10.3791/59132-v

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04:23 min

April 28, 2019

•

2 Views

Ting-Jing Shen^1,2, Ming-Kai Jhan^1,2, Jo-Chi Kao^1,2, Min-Ru Ho^1,2, Tsung-Ting Tsai^1,2, Po-Chun Tseng^1,2, Yung-Ting Wang^1,2, Chiou-Feng Lin^1,2,3

¹Graduate Institute of Medical Sciences, College of Medicine,Taipei Medical University, ²Department of Microbiology and Immunology, School of Medicine, College of Medicine,Taipei Medical University, ³Center of Infectious Disease and Signaling Research,National Cheng Kung University

Summary

在这里,我们提出了一个协议,创建一个免疫能力ICR(癌症研究所)的中枢神经系统感染的鼠模型,以显示神经病变的发展。通过相同的疾病评分监测急性病毒性脑病,可以显示体内登革热病毒引起的神经病变。

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