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采用多段注射-毛细管电泳质谱法进行高通量和综合药物监测
JoVE Journal
Química
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JoVE Journal Química
High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
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采用多段注射-毛细管电泳质谱法进行高通量和综合药物监测

DOI:
10.3791/58986-v

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10:17 min

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April 23, 2019

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, , , , , , ,
1Department of Chemistry and Chemical Biology,McMaster University, 2Agilent Technologies Inc., 3Seroclinix Corporation

Capítulos

  • 00:04Título
  • 01:10Urine Sample Preparation
  • 02:12Capillary Electrophoresis-Time-of-Flight-Mass Spectrometer (CE-TOF-MS) System Setup
  • 04:29CE Injection and Separation Condition Setup
  • 05:31TOF-MS Setup
  • 06:36Data Analysis
  • 07:41Results: Representative High-throughput and Comprehensive Drug Surveillance
  • 09:25Conclusion

Summary

Tadução automática

Tadução automática

在这里, 我们描述了一种用于全面药物监测的高通量方法, 该方法可以提高大型药物滥用药物及其代谢物的分辨率和检测能力, 并在多段注射-毛细管的基础上进行质量控制电泳质谱。

Tags

High-throughputComprehensiveDrug SurveillanceMultisegment InjectionCapillary ElectrophoresisMass SpectrometryUrine Drug ScreeningTherapeutic Drug MonitoringMetabolite ProfilingTargeted AnalysisNon-targeted AnalysisSample PreparationCapillary ConditioningCE-MS

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