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High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
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Chemie
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JoVE Journal Chemie
High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

9,194 Views

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10:17 min

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April 23, 2019

DOI:

10.3791/58986-v

DOI:
10.3791/58986-v

•

10:17 min
April 23, 2019

•

11 Views
, , , , , , ,
1Department of Chemistry and Chemical Biology,McMaster University, 2Agilent Technologies Inc., 3Seroclinix Corporation

Summary

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Here we describe a high-throughput method for comprehensive drug surveillance that allows for the improved resolution and detection of large panels of drugs of abuse and their metabolites, with quality control based on multisegment injection-capillary electrophoresis-mass spectrometry.

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High-throughputComprehensiveDrug SurveillanceMultisegment InjectionCapillary ElectrophoresisMass SpectrometryUrine Drug ScreeningTherapeutic Drug MonitoringMetabolite ProfilingTargeted AnalysisNon-targeted AnalysisSample PreparationCapillary ConditioningCE-MS

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Shanmuganathan, M., Macklai, S., Barrenas Cárdenas, C., Kroezen, Z., Kim, M., Zizek, W., Lee, H., Britz-McKibbin, P. High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry. J. Vis. Exp. (146), e58986, doi:10.3791/58986 (2019).

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