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Implantation of hiPSC-derived Cardiac-muscle Patches after Myocardial Injury in a Guinea Pig Model
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JoVE Journal Medicina
Implantation of hiPSC-derived Cardiac-muscle Patches after Myocardial Injury in a Guinea Pig Model

Implantation of hiPSC-derived Cardiac-muscle Patches after Myocardial Injury in a Guinea Pig Model

DOI:
10.3791/58810-v

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07:03 min

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March 18, 2019

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, , , , , , , ,
1Department of Cardiovascular Surgery,University Heart Center Hamburg, 2partner site Hamburg/Kiel/Lübeck,German Centre for Cardiovascular Research (DZHK), 3Department of Experimental Pharmacology and Toxicology, Cardiovascular ResearchCenter,University Medical Center Hamburg-Eppendorf

Capítulos

  • 00:04Título
  • 00:33Transthoracic Echocardiography
  • 01:27Myocardial Infarction Induction
  • 04:10Engineered Heart Tissue (EHT) Implantation
  • 05:21Results: Representative Human Engineered Heart Tissue (hEHT) Patch Analyses
  • 06:05Conclusion

Summary

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Tadução automática

Here we present a protocol for the induction of left ventricular cryoinjury followed by the implantation of a cardiac muscle patch, derived from human iPS-cell cardiomyocytes in a guinea pig model.

Tags

Keywords: HiPSC-derived Cardiac-muscle PatchesMyocardial InjuryGuinea Pig ModelCryoinfarction ModelEchocardiographyTracheal IntubationThoracotomyLeft Ventricular Cryoinjury

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