Tameness in animals includes a reduction of avoidance responses to humans (passive tameness) and an increase in active approaches to humans (active tameness). Here, we describe detailed protocols for three behavioral tests (active tameness, passive tameness, and stay-on-hand tests) to separately measure the active and passive tameness of mice.
Nagayama, H., Matsumoto, Y., Tanave, A., Nihei, M., Goto, T., Koide, T. Measuring Active and Passive Tameness Separately in Mice. J. Vis. Exp. (138), e58048, doi:10.3791/58048 (2018).