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In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration
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In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration
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June 15, 2018
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The measurement of nerve conduction is a useful tool to assess mouse models of neurodegeneration but it is frequently only applied to stimulate the sciatic nerve in hindlimbs. Here, we describe a technique to measure compound muscle action potential (CMAP) in vivo in the mouse forelimb muscles innervated by the brachial plexus.
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In Vivo ElectrophysiologyCompound Muscle Action PotentialMouse ModelsMotor Neuron DegenerationAxon DegenerationDemyelinationPeripheral NervesMinimally InvasiveRepeated MeasurementsSensitivityEarly DetectionAnesthesiaBody Temperature RegulationElectrode PlacementForelimbHind LimbSciatic NerveGastrocnemius MuscleBrachial PlexusBiceps Brachii
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Pollari, E., Prior, R., Robberecht, W., Van Damme, P., Van Den Bosch, L. In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration. J. Vis. Exp. (136), e57741, doi:10.3791/57741 (2018).
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