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骨科手术的小鼠模型研究术后认知功能障碍与组织再生
JoVE Journal
Medicina
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JoVE Journal Medicina
A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
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骨科手术的小鼠模型研究术后认知功能障碍与组织再生

DOI:
10.3791/56701-v

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08:17 min

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February 27, 2018

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, , ,
1Department of Anesthesiology,Duke University Medical Center, 2Department of Orthopaedic Surgery,Duke University Medical Center, 3Duke Molecular Physiology Institute, 4Center for Translational Pain Medicine,Duke University Medical Center

Capítulos

  • 00:05Título
  • 00:50Preoperative Setup for Parabiosis and Orthopedic Surgery
  • 01:48Parabiosis Surgery
  • 04:02Tibial Fracture Surgery
  • 06:23Results: Parabiosis Surgery Leads to Rejuvenation of Fracture Healing, Blood-sharing, and Donor-cell Engraftment
  • 07:36Conclusion

Summary

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Tadução automática

本协议描述了一种用于研究术后 neuroinflammation 和行为变化机制的骨科手术小鼠模型, 并结合联体共生, 研究了衰老过程中的组织再生。

Tags

Orthopedic SurgeryParabiosisPostoperative Cognitive DysfunctionImmunologyAgingTraumaMulti-organ DysfunctionRegenerative EffectsCognitive FunctionAnesthesiaAnalgesiaSurgical Procedure

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