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マウス骨髄と腹腔マクロファージ活性化抗体を用いた薬剤効果の評価
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Imunologia e Infecção
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JoVE Journal Imunologia e Infecção
Assessment of Antibody-based Drugs Effects on Murine Bone Marrow and Peritoneal Macrophage Activation
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マウス骨髄と腹腔マクロファージ活性化抗体を用いた薬剤効果の評価

8,056 Views

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10:35 min

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December 26, 2017

DOI:

10.3791/56689-v

DOI:
10.3791/56689-v

•

10:35 min
December 26, 2017

•

13 Views
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1British Columbia Children’s Hospital Research Institute,University of British Columbia

Summary

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抗体創薬が炎症性疾患の治療に革命をもたらしました。特定のターゲットに対する直接的な効果だけでなく、抗体は抗炎症になる大食細胞をアクティブ化できます。このプロトコルを記述する方法抗炎症マクロファージ活性化は評価in vitroマウス骨髄マクロファージと生体内のマクロファージを使用して使用することができます。

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Cite this Article

Kozicky, L., Sly, L. M. Assessment of Antibody-based Drugs Effects on Murine Bone Marrow and Peritoneal Macrophage Activation. J. Vis. Exp. (130), e56689, doi:10.3791/56689 (2017).

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