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A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
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Capítulos
- 00:04Título
- 00:36Adaptive Tracking Test
- 01:35Saccadic Eye Movement and Smooth Pursuit Test
- 03:28Visual Analog Scale, Body Sway and Visual Verbal Learning Test
- 05:32Results: Effect of Placebo, Mecamylamine, and Scopolamine on the Adaptive Tracking Test in Healthy Young Males
- 06:08Conclusion
A validated computerized battery of neuropsychological and neurophysiological tests is used to study pharmacodynamic effects on the central nervous system of newly developed drugs in early phase development. To demonstrate the test battery, the acute effects of mecamylamine and the reversal of these effects by two agonist drugs are described.
