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JoVE Journal Neuroscience
Sagittal Plane Kinematic Gait Analysis in C57BL/6 Mice Subjected to MOG35-55 Induced Experimental Autoimmune Encephalomyelitis
 

Sagittal Plane Kinematic Gait Analysis in C57BL/6 Mice Subjected to MOG35-55 Induced Experimental Autoimmune Encephalomyelitis

Article DOI: 10.3791/56032-v • 13:02 min • November 4th, 2017
November 4th, 2017 •
*1, *1, 1, 2, 1,3
1Pharmacology, Dalhousie University, 2Medical Neuroscience, Dalhousie University, 3Psychiatry, Dalhousie University
* These authors contributed equally

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Kinematic gait analysis in the sagittal plane yields highly precise information about how movement is executed. We describe the application of these techniques to identify gait deficits for mice subjected to autoimmune-mediated demyelination. These methods may also be used to characterize gait deficits for other mouse models featuring impaired locomotion.

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Kinematic Gait Analysis Sagittal Plane C57BL/6 Mice MOG35-55 Induced Experimental Autoimmune Encephalomyelitis EAE Mouse Model Multiple Sclerosis Neurological Deficits Neural Inflammation White Matter Loss Motor Stability Assessment Clinical Scoring Systems Spinal Cord Histopathology Walking Deficits Reflective Markers High-speed Camera Motion Analysis Software
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