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JoVE Journal Biochemistry
Mimicking the Function of Signaling Proteins
 

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy

Article DOI: 10.3791/54396-v • 12:24 min • September 29th, 2016
September 29th, 2016 •
1, 1, 1
1Department of Organic Chemistry, Weizmann Institute of Science

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We present guidelines for developing synthetic 'chemical transducers' that can induce communication between naturally unrelated proteins. In addition, detailed protocols are presented for synthesizing and testing a specific 'transducer' that enables a growth factor to activate a detoxifying enzyme and consequently, to regulate the cleavage of an anticancer prodrug.

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Signaling Proteins Artificial Signal Transduction Therapy Synthetic Chemical Transducer Protein Communication Spectrophotometer Artificial Chemical Transducers Platelet Derived Growth Factor (PDGF) Aptamer Ethacrynic Amide GST Inhibitor Fluorophore Quencher Enzyme Inhibition PDGF Chemical Transducer Complex Enzyme Activity Control
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