Here, we show the pressure injection of neuropharmacological substances during single-cell recording in an awake, behaving macaque monkey. This procedure allows pharmacological manipulation in the direct vicinity of a cortical recording site.
Veith, V. K., Quigley, C., Treue, S. A Pressure Injection System for Investigating the Neuropharmacology of Information Processing in Awake Behaving Macaque Monkey Cortex. J. Vis. Exp. (109), e53724, doi:10.3791/53724 (2016).