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Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
JoVE Journal
Medicina
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JoVE Journal Medicina
Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

18,604 Views

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08:12 min

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July 15, 2015

DOI:

10.3791/52909-v

DOI:
10.3791/52909-v

•

08:12 min
July 15, 2015

•

8 Views
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1Multi Organ Transplant Program, Department of Surgery,Toronto General Hospital, 2Division of Nephrology,The Hospital for Sick Children, Toronto, 3Department of General, Visceral & Transplant Surgery,University Medical Center Mainz, 4Department of Abdominal, Vascular & Transplant Surgery,Merheim Medical Center Cologne, 5Laboratory Medicine & Pathobiology,Toronto General Hospital, 6Departments of Surgery (Urology) & Physiology,The Hospital for Sick Children, Toronto, 7Developmental & Stem Cell Biology,The Hospital for Sick Children, Toronto

Summary

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The severe organ shortage has resulted in increased use of marginal kidney grafts for transplantation. This has triggered interest in alternative storage methods, since marginal grafts especially tolerate cold storage poorly. The technique of normothermic ex vivo kidney perfusion (NEVKP) represents a novel preservation method for kidney grafts prior to  transplantation.

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Kaths, J. M., Spetzler, V. N., Goldaracena, N., Echeverri, J., Louis, K. S., Foltys, D. B., Strempel, M., Yip, P., John, R., Mucsi, I., Ghanekar, A., Bagli, D., Robinson, L., Selzner, M. Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation. J. Vis. Exp. (101), e52909, doi:10.3791/52909 (2015).

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