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成人人成纤维细胞的推导和他们直接转换成可扩展的神经祖细胞
JoVE Journal
Neurociência
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JoVE Journal Neurociência
Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells
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成人人成纤维细胞的推导和他们直接转换成可扩展的神经祖细胞

15,225 Views

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13:58 min

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July 29, 2015

DOI:

10.3791/52831-v

DOI:
10.3791/52831-v

•

13:58 min
July 29, 2015

•

3 Views
, , , ,
1Institute of Anatomy and Cell Biology,University of Würzburg, 2Institute of Reconstructive Neurobiology,University of Bonn, 3German Cancer Research Center, Heidelberg

Summary

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诱导多能干细胞的产生提供了用于自体移植的推导引人入胜的前景。然而，通过多能状态和艰苦的再分化仍然进展阻碍临床翻译。在这里，我们描述了成年人成纤维细胞的衍生和其直接转化为诱导神经祖细胞和随后的分化成神经谱系。

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Meyer, S., Wörsdörfer, P., Günther, K., Thier, M., Edenhofer, F. Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells. J. Vis. Exp. (101), e52831, doi:10.3791/52831 (2015).

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