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전방 시상 핵의 깊은 뇌 자극 후 쥐 해마의 유전자 발현 변화 분석
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Neurociência
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JoVE Journal Neurociência
Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
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전방 시상 핵의 깊은 뇌 자극 후 쥐 해마의 유전자 발현 변화 분석

10,708 Views

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09:46 min

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March 08, 2015

DOI:

10.3791/52457-v

DOI:
10.3791/52457-v

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09:46 min
March 08, 2015

•

4 Views
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1Department of Neurosurgery,Brigham & Women’s Hospital, Harvard Medical School, 2Division of Brain Sciences, Department of Medicine,Imperial College London

Summary

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The mechanism underlying the therapeutic effects of Deep Brain Stimulation (DBS) surgery needs investigation. The methods presented in this manuscript describe an experimental approach to examine the cellular events triggered by DBS by analyzing the gene expression profile of candidate genes that can facilitate neurogenesis post DBS surgery.

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Selvakumar, T., Alavian, K. N., Tierney, T. Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus. J. Vis. Exp. (97), e52457, doi:10.3791/52457 (2015).

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