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Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
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JoVE Revista Neurociencias
Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

DOI:
10.3791/52457-v

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09:46 min

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March 08, 2015

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, ,
1Department of Neurosurgery,Brigham & Women’s Hospital, Harvard Medical School, 2Division of Brain Sciences, Department of Medicine,Imperial College London

Capítulos

  • 00:05Título
  • 01:38Presurgical Preparation
  • 03:04Deep Brain Stimulation Surgery
  • 06:45Hippocampus Isolation
  • 07:49Results: Gene Expression Changes After Deep Brain Stimulation of the Anterior Thalamic Nucleus
  • 08:59Conclusion

Summary

Traducción Automática

Traducción Automática

The mechanism underlying the therapeutic effects of Deep Brain Stimulation (DBS) surgery needs investigation. The methods presented in this manuscript describe an experimental approach to examine the cellular events triggered by DBS by analyzing the gene expression profile of candidate genes that can facilitate neurogenesis post DBS surgery.

Tags

Gene ExpressionDeep Brain StimulationAnterior Thalamic NucleusRat HippocampusQuantitative RT-PCRStereotactic SurgeryNeurogenesisEpilepsyBasal Ganglia

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