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Journal / Developmental Biology / 基于发育毒性测定化学品安全筛选和系统生物学数据生成人类多能干细胞…
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JoVE Journal Developmental Biology
基于发育毒性测定化学品安全筛选和系统生物学数据生成人类多能干细胞
 
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基于发育毒性测定化学品安全筛选和系统生物学数据生成人类多能干细胞

Article DOI: 10.3791/52333-v • 17:28 min • June 17th, 2015
June 17th, 2015 •
*1, *2, 1, 1, 1, 3, 3, 4, 2, 1, *2, *1
1Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, 2Department of Biology, University of Konstanz, 3Department of Statistics, Technical University of Dortmund, 4Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund
* These authors contributed equally

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该协议描述了基于人胚胎干细胞和转录研究2 在体外发育毒性试验系统（UKK和UKN1）。测试系统预测人类发育毒性危险，并可能有助于减少动物研究中，成本和所需的化学安全测试的时间。

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发育生物学，第100，人类胚胎干细胞，发育毒性，神经毒性，神经外胚层祖细胞，免疫沉淀，分化，细胞毒性，embryopathy，胚状体
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