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Chirurgische methode voor viraal gemedieerde Gene Levering aan de Mouse Inner Ear door het ronde venster membraan
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Chirurgische methode voor viraal gemedieerde Gene Levering aan de Mouse Inner Ear door het ronde venster membraan
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07:32 min
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March 16, 2015
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Summary
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The described post-auricular surgical approach allows rapid and direct delivery into the mouse cochlear scala tympani while minimizing blood loss and animal mortality. This method can be used for cochlear therapy using molecular, pharmacologic and viral delivery to postnatal mice through the round window membrane.
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Akil, O., Rouse, S. L., Chan, D. K., Lustig, L. R. Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane. J. Vis. Exp. (97), e52187, doi:10.3791/52187 (2015).
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