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杀手人工抗原提呈细胞（KaAPC）为有效<em>在体外</em>人抗原特异性T细胞耗竭

JoVE Journal
Imunologia e Infecção

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JoVE Journal Imunologia e Infecção

Killer Artificial Antigen Presenting Cells (KaAPC) for Efficient In Vitro Depletion of Human Antigen-specific T Cells

Please note that all translations are automatically generated. Click here for the English version.

杀手人工抗原提呈细胞（KaAPC）为有效<em>在体外</em>人抗原特异性T细胞耗竭

DOI:

10.3791/51859-v

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08:12 min

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August 11, 2014

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Christian Schütz, Martin Fleck³, Jonathan P. Schneck, Mathias Oelke

¹Department of Pathology, Institute of Cell Engineering,Johns Hopkins University, ²Department of Internal Medicine I,University of Regensburg, ³Department of Rheumatology,Asklepios Medical Center

Capítulos

00:05Título
01:32Generation of HLA-A2-Ig Based Killer Artificial Antigen Presenting Cells (KaAPC)
03:19Quality Control, Peptide Loading, Washing, Storage, and Stability of KaAPC
04:53KaAPC In Vitro Killing Assay
06:23Results: KaAPC Eliminate CTL in an Antigen-specific Fashion
07:43Conclusion

Summary

Tadução automática

准则都用于杀伤人工抗原的产生呈递细胞，KaAPC，用于体外耗尽人抗原特异性T细胞的和在一个抗原的替代解决方案，以细胞免疫治疗对T细胞介导的自身免疫性疾病的治疗中的有效工具具体的方式不影响剩余的免疫系统。

Tags

Keywords: Killer Artificial Antigen Presenting Cells KaAPC In Vitro T Cell Depletion Autoimmune Disease Treatment Cell-based Immunotherapy Antigen-specific T Cell Modulation Global Immunosuppression Tolerance-inducing Antigen Presenting Cells

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