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Killer Artificial Antigen Presenting Cells (KaAPC) for Efficient In Vitro Depletion of Human Antigen-specific T Cells
JoVE Journal
Immunology and Infection
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JoVE Journal Immunology and Infection
Killer Artificial Antigen Presenting Cells (KaAPC) for Efficient In Vitro Depletion of Human Antigen-specific T Cells

Killer Artificial Antigen Presenting Cells (KaAPC) for Efficient In Vitro Depletion of Human Antigen-specific T Cells

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9,564 Views

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08:12 min

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August 11, 2014

DOI:

10.3791/51859-v

DOI:
10.3791/51859-v

•

08:12 min
August 11, 2014

•

7 Views
, , ,
1Department of Pathology, Institute of Cell Engineering,Johns Hopkins University, 2Department of Internal Medicine I,University of Regensburg, 3Department of Rheumatology,Asklepios Medical Center

Summary

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Guidelines are presented for the generation of killer artificial antigen presenting cells, KaAPC, an efficient tool for in vitro depletion of human antigen-specific T cells and an alternative solution to cellular immunotherapy for the treatment of T cell-mediated autoimmune diseases in an antigen-specific fashion without compromising the remaining immune system.

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Cite this Article

Schütz, C., Fleck, M., Schneck, J. P., Oelke, M. Killer Artificial Antigen Presenting Cells (KaAPC) for Efficient In Vitro Depletion of Human Antigen-specific T Cells. J. Vis. Exp. (90), e51859, doi:10.3791/51859 (2014).

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