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Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
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Engenharia
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JoVE Journal Engenharia
Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

DOI:
10.3791/51081-v

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09:43 min

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October 31, 2013

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, , ,
1Department of Physics,University of Ottawa, 2Ottawa-Carleton Institute of Biomedical Engineering,University of Ottawa

Capítulos

  • 00:05Título
  • 01:36Nanopore Characterization
  • 03:13Conditioning Nanopores Using High Electric Fields
  • 04:25Enlarging Nanopores Using High Electric Fields
  • 06:41DNA Translocation
  • 08:02Results: Effects of High Electric Fields on Nanopore Properties and Functionality
  • 09:12Conclusion

Summary

Tadução automática

Tadução automática

A methodology for preparing solid-state nanopores in solution for biomolecular translocation experiments is presented. By applying short pulses of high electric fields, the nanopore diameter can be controllably enlarged with subnanometer precision and its electrical noise characteristics significantly improved. This procedure is performed in situ using standard laboratory equipment under experimental conditions.

Tags

Solid-state NanoporesSingle Biomolecule CharacterizationNanopore FabricationSize ControlLow-noise PerformanceHigh Electric Field PulsesIn Situ EnlargementAqueous EnvironmentReproducibility

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