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Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer’s Disease and Normal Elderly
JoVE Journal
Medicina
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JoVE Journal Medicina
Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer’s Disease and Normal Elderly

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer’s Disease and Normal Elderly

39,318 Views

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12:50 min

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April 14, 2014

DOI:

10.3791/50887-v

DOI:
10.3791/50887-v

•

12:50 min
April 14, 2014

•

17 Views
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1LC Campbell Cognitive Neurology Research Unit, Heart & Stroke Foundation Canadian Partnership for Stroke Recovery, Brain Sciences Research Program,Sunnybrook Health Sciences Centre, 2Department of Medicine (Neurology), Institute of Medical Science,University of Toronto

Summary

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Lesion Explorer (LE) is a semi-automatic, image-processing pipeline developed to obtain regional brain tissue and subcortical hyperintensity lesion volumetrics from structural MRI of Alzheimer's disease and normal elderly. To ensure a high level of accuracy and reliability, the following is a video-guided, standardized protocol for LE's manual procedures.

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Ramirez, J., Scott, C. J., McNeely, A. A., Berezuk, C., Gao, F., Szilagyi, G. M., Black, S. E. Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly. J. Vis. Exp. (86), e50887, doi:10.3791/50887 (2014).

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