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Retinal Detachment Model in Rodents by Subretinal Injection of Sodium Hyaluronate
JoVE Journal
Medicina
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JoVE Journal Medicina
Retinal Detachment Model in Rodents by Subretinal Injection of Sodium Hyaluronate

Retinal Detachment Model in Rodents by Subretinal Injection of Sodium Hyaluronate

DOI:
10.3791/50660-v

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05:58 min

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September 11, 2013

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, ,
1Retina Service, Angiogenesis Laboratory, Department of Ophthalmology,Massachusetts Eye and Ear Infirmary, Harvard Medical School

Capítulos

  • 00:05Título
  • 02:17Surgery
  • 04:42Results: Time Course of Retinal Detachment
  • 05:16Conclusion

Summary

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Creating experimental retinal detachments with a reproducible and sustained height of detachment, and without subretinal hemorrhage, is important for studying the pathophysiology of photoreceptor cell loss in retinal disease and evaluating potential therapeutic interventions. Here, we report such a method in detail.

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Keywords: Retinal DetachmentSubretinal InjectionSodium HyaluronatePhotoreceptor Cell DeathSelf-sealing Scleral IncisionChoroidal HemorrhageRhegmatogenous Retinal DetachmentRetinopathy Of PrematurityDiabetic RetinopathyCentral Serous ChorioretinopathyAge-related Macular Degeneration

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